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如何保持一个斑马鱼大脑神经再生能力

2015年05月18日 浏览量: 评论(0) 来源:Science期刊 作者:Science期刊 责任编辑:admin
摘要:即使在斑马鱼的大脑,这个似乎可以比人类的大脑产生更好的产生新的神经元大脑里,再生能力可能不是无限的。巴博萨等人描绘出单个斑马鱼神经细胞与时间变化。
    即使在斑马鱼的大脑,这个似乎可以比人类的大脑产生更好的产生新的神经元大脑里,再生能力可能不是无限的。巴博萨等人描绘出单个斑马鱼神经细胞与时间变化。研究发现,神经干细胞维持神经元的数量,但不是完全替代,当脑部发生损伤时候,更多的干细胞被拉进神经通路,剩下更少的部分满足未来的替代的需要。
 
原文链接:
 
Live imaging of adult neural stem cell behavior in the intact and injured zebrafish brain
 
原文摘要:
 
    Adult neural stem cells are the source for restoring injured brain tissue. We used repetitive imaging to follow single stem cells in the intact and injured adult zebrafish telencephalon in vivo and found that neurons are generated by both direct conversions of stem cells into postmitotic neurons and via intermediate progenitors amplifying the neuronal output. We observed an imbalance of direct conversion consuming the stem cells and asymmetric and symmetric self-renewing divisions, leading to depletion of stem cells over time. After brain injury, neuronal progenitors are recruited to the injury site. These progenitors are generated by symmetric divisions that deplete the pool of stem cells, a mode of neurogenesis absent in the intact telencephalon. Our analysis revealed changes in the behavior of stem cells underlying generation of additional neurons during regeneration.
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